Homework and readings for Dec 2, 2008

Everyone reads the "MinireviewMultisite"

Desahies and Ferrell, Multisite phosphorylation and the countdown to S phase Cell, Dec. 28, 2001.

xxx read the TyersMath paper.
Klein, Pawson, Tyers (2003). Mathematical Modeling Suggests Cooperative Inteactions between a disordered polyvalent ligand and a single receptor site.

Everyone else read the MultisitephosNature paper.
Nash .....and Tyers (2001). Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature

Homework
1. Describe the big picture of this story (drawn from any of the readings) and if you think its likely to be generally relevant in biology.
2, And, describe briefly two figures from the research paper you read. One figure is the KEY FIGURE as you see it. And, a second figure is any other one in that article. (Be ready, however, to have to discuss in your subgroups any figure that is then presented to the super group!)

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